Locally delivered antioxidant gel as an adjunct to nonsurgical therapy improves measures of oxidative stress and periodontal disease
Chandra Rampalli Viswa, Srinivas Gorremuchu, Reddy Aileni Amarender, Reddy Bavigadda Harish, Reddy Chakravarthy, Nagarajan Sripriya, Naveen Anumala,
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( Chandra Rampalli Viswa ) - SVS Institute of Dental Sciences Department of Periodontics
( Srinivas Gorremuchu ) - SVS Institute of Dental Sciences Department of Periodontics
( Reddy Aileni Amarender ) - SVS Institute of Dental Sciences Department of Periodontics
( Reddy Bavigadda Harish ) - SVS Institute of Dental Sciences Department of Periodontics
( Reddy Chakravarthy ) - SVS Institute of Dental Sciences Department of Periodontics
( Nagarajan Sripriya ) - SVS Institute of Dental Sciences Department of Preventive and Community Dentistry
( Naveen Anumala ) - SVS Institute of Dental Sciences Department of Periodontics
KMID : 0363020130430030121
Abstract
Purpose: The present study has two aims; firstly, it attempts to verify the presence of oxidative stress by estimating the reactive oxygen species (ROS) levels in periodontal pockets ≥5 mm as compared to controls. The second aim is to evaluate the effect of lycopene as a locally delivered antioxidant gel on periodontal health and on the gingival crevicular fluid (GCF) levels of 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative injury.
Methods: Thirty-one subjects participated in this study. In the pretreatment phase, the ROS levels in pockets ≥5 mm were measured by flow cytometry. Three sites in each subject were randomly assigned into each of the following experimental groups: sham group, only scaling and root planing (SRP) was done; placebo group, local delivery of placebo gel after SRP; and lycopene group, local delivery of lycopene gel after SRP. Clinical parameters included recording site-specific measures of GCF 8-OHdG, plaque, gingivitis, probing depth, and clinical attachment level.
Results: The gel, when delivered to the sites with oxidative stress, was effective in increasing clinical attachment and in reducing gingival inflammation, probing depth, and 8-OHdG levels as compared to the placebo and sham sites.
Conclusions: From this trial conducted over a period of 6 months, it was found that locally delivered lycopene seems to be effective in reducing the measures of oxidative stress and periodontal disease.
키워드
Antioxidants ; Oxidative stress ; Periodontitis
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